Molecular Formula | C5H7N5O |
Molar Mass | 153.14 |
Storage Condition | −20°C |
In vitro study | In the absence of the external field the FAPy-adenine is able to form pairs with all four canonical nucleic acid bases. In contrast, in the presence of the external field the mispairing abilities of FAPy-adenine become insignificant since the most stable dimers are formed with thymine. |
In vivo study | The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease. |
WGK Germany | 3 |
biological activity | FAPy-adenine is an oxidized DNA base. FAPy-adenine in the brain of Alzheimer's disease is on the rise. Oxidized nucleosides are biochemical markers of cancer, aging and neurodegenerative diseases. |